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HSD17B10: A gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids

.....This gene encodes HSD10, a mitochondrial multifunctional enzyme that plays a significant part in the metabolism of neuroactive steroids and the degradation of isoleucine.......

....HSD10 inactivates the positive modulators of GABAA receptors, and plays a role in the maintenance of GABAergic neuronal function......

Molecular Genetics and Metabolism
Volume 92, Issues 1-2, September-October 2007,

http://www.sciencedirect.com/science...e05248e6c2186f

http://beta.uniprot.org/uniprot/Q99714