A paper proposing permeability of the BBB is the cause of many CNS disorders. Why are these papers ignored by big pharma.?
A. Because they have 5 million captive customers for life, that they don't want cured.
Ron

Med Hypotheses. 2001 Aug;57(2):231-7.

Chronic fatigue syndrome: neurological findings may be related to blood--brain
barrier permeability.

Bested AC, Saunders PR, Logan AC.

Environmental Health Clinic, Sunnybrook and Women's College, Health Sciences
Centre, Toronto, Canada.

Despite volumes of international research, the etiology of chronic fatigue
syndrome (CFS) remains elusive. There is, however, considerable evidence that CFS
is a disorder involving the central nervous system (CNS). It is our hypothesis
that altered permeability of the blood-brain barrier (BBB) may contribute to
ongoing signs and symptoms found in CFS. To support this hypothesis we have
examined agents that can increase the blood-brain barrier permeability (BBBP) and
those that may be involved in CFS. The factors which can compromise the normal
BBBP in CFS include viruses, cytokines, 5-hydroxytryptamine, peroxynitrite,
nitric oxide, stress, glutathione depletion, essential fatty acid deficiency, and
N-methyl-D-aspartate overactivity. It is possible that breakdown of normal BBBP
leads to CNS cellular dysfunction and disruptions of neuronal transmission in
CFS. Abnormal changes in BBBP have been linked to a number of disorders involving
the CNS; based on review of the literature we conclude that the BBB integrity in
CFS warrants investigation.

PMID: 11461179

------------------------------------------------------------------------