This whole business of investigative new drugs and the obvious need for more , larger, and testing of greater complexity in Human trials , when it was obvious that the animal tests were not translating well into the human and became increasingly more perplexing, we would often say in exasperation " what the hell are we suppossed to do, test our new drugs in human babies". Of course it was never meant to infer that further extensive human clinical trials should not be done, and NOBODY ever wanted to cut things short and lose ten times what the expected profit margins were in litigations, but clinical trials in a population of unhealthy patients (the only ones who were willing to sign off on the no contest papers), often gave results that sent many a good medicine down the drain. What's a drug research company to do? THe terrible truth is that there is always a generation that has to "pay" by taking chances for a good medication to come on stream. I don't think that will ever change. Just look at Mercks COX2 inhibitor that almost destroyed one of the country's largest drug manufacturers?