I had DBS 3 weeks ago, activated on 10/15. So far I feel I am on a very aggressive medication schedule. I too was very surprised that this did not suddenly change my medication requirements. My neuro has led me to believe that this will improve as my body adjust to the leads, etc. and as I heal. There are so many variables in the equation, many components of the settings such as the lead setup, pulse rate, frequency,amplitude, voltage. I am at 1 volt on the left/ 1.5 on the right. The literature I have read in my manual says that the typical setting is around 3v. So I have a long way to go, lots of room for adjustment. He has told me that the objective is the least amount to get the job done. That said, I have not decreased my meds-I only take Sinemet but I take it 1 tab every 2hrs. So many other things have improved for me. Absolutely no dyskinesia, NONE. I can pretty much be "on" all day, no sudden off,etc. That tells me that there may be some room there for spacing this out some. But yes, I definitely think you will see a difference. I was taking Stalevo 400/mo, Amatadine 100/mo. Now that's down to about 120/mo for the Sinemet.