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Old 11-11-2007, 06:06 PM
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mrsD mrsD is offline
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Join Date: Aug 2006
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb Check out Linus Pauling Institute:

Quote:
Toxicity

No toxic or adverse effects have been associated with large intakes of vitamin B12 from food or supplements in healthy people. Doses as high as 1 mg (1000 mcg) daily by mouth or 1 mg monthly by intramuscular (IM) injection have been used to treat pernicious anemia without significant side effects. When high doses of vitamin B12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity. Because of the low toxicity of vitamin B12, no tolerable upper intake level (UL) was set by the Food and Nutrition Board in 1998 when the RDA was revised (6).
http://lpi.oregonstate.edu/infocente...B12/index.html

When you use 1000mcg daily orally/sublingually, 10mcg or less are absorbed.
There are not toxicity studies available on high dose B12 yet. Some Japanese studies on MS used 40 milligrams a day oral.

Injecting mega amounts daily (abuse for some weight loss treatments) may be another factor. Cyano form does not agree with everyone. Some cannot handle the cyanide portion. That is why many recommend methyl orally, and also because this form works better and faster (needs no conversion in the body) Cyano is a synthetic chemical, our bodies cannot use without conversion.

Take all oral/sublingual forms on an empty stomach for best results.
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