I only use Aleve 220mg every once in a while...not everyday or all day long.
I see a physician regularly and have renal panel done every 6mos.

I am not considered a renal risk still after many years using on and off NSAIDs.

I found SAMe superior to NSAIDs anyway, and only use NSAIDs before expected more than average physical activity (i.e. the gym).

I still have normal serum creatinine and no interactions with blood pressure at the low dose I use.

NSAIDs are one of the most frequently reported drugs for injury and death.

Some statistics:
http://www.drugwarfacts.org/causes.htm
http://www.postgradmed.com/issues/20...1/fennerty.htm
Both of these links give pretty grim statistics on injury potential from NSAIDs.

This is a site that lists FDA reports for Mobic:
http://patientsville.com/medication/...de_effects.htm

The numbers are not high, because Mobic is not a hugely commonly used drug. And it is not available OTC. It is not a "fast mover" by any means.

Here is the Naprosyn one by comparison:
http://patientsville.com/medication/...de_effects.htm

similar in type, only less #s reported. All NSAIDs affect kidney functions. In some people dramatically and others less so. BTW my neighbor had a near fatal bleed on Naprosyn and was in intensive care for 13 days. She used it heavily and long term. I use predominately SAMe and fish oil by comparison.