MS frequently causes Central Pain Syndrome, which is a condition that does not respond to opiates. I was recently dx'd w/ this after suffering w/ RSD in both legs since 2001. This pain overwhelms my RSD pain & none of my opiate pain meds, including methadone, relieves the pain. A recent trip to the ER & 5mg's of dilaudid did absolutely nothing. The regimen of meds your brother is one similar to ones recommended by many but even the NIH admits there is no treatment. I'm sorry. I wish you & your brother the best of luck. My prayers are w/ both of you.
Gramps