Hello,

I am Anne, a french PwP, I was a MD, specialist in gynaecology and oncology surgery before day of diagnosis of own PD in 1999, at 42 years of age.

I have "some ideas" about dopaminergic drugs optimization as,in fact, I have led a huge work on my own, during several years upon the very subject.

In 2001, I had first worked upon mechanisms of drugs addiction and withdrawal troubles as I wanted to confirm my hypothesis levodopa therapy motor complications may present similar mechanisms.
Then with the knowledge I had acquired from excellent works in toxicology and psychopharmacology of reward circuitries, I "naturally" extended then my works upon dopaminergic drugs in nigrostriatal pathways.
I was then contacted by group of frech engineers who had started a manual method for optimization and they asked me to make somthing from it.
I must say all my admiration for al they had done , it was odf great help to me. But nobody inneurology had agreed to listen to them ;
As nothing was referenced in their work and they had no idea about mechanisms, they encourage me to go on. This is how I led new bibliographic research, still on my own, ran a meta-analysis of almost all the international and multicentric essays for each drug, each presentation, each bi-therapy protocol and same with COMT and MAO B inhibitors and have read and worked upon loads of articles upon same subject.
This is how I succeeded after 3.5 years of really tough work to list with scientific references almost all pharmacokinetic data ((Cmax,T max and half life, whole work is about 500-600 references).
Two french neuropharmacologists I met to compare with their knowledge were absolutely astonished to see I had found all the others, and indeed some were not even listed in the US pharmacologists
database at that time, in November2004. A french engineer PwP’s too and working with me in Mediapark the association I have founded in Lyon has then defined mathematics for a computerized application we have now since end of Spring 2005.
-following lines coming soon-