Hey, Matt.
It is true that some of us have a difficult time with elevation and changes in air pressure. Many people get headaches, balance problems, and even seizures from them. I have a cluster of simple partial seizures with each season change.
If the elevation is an issue, you'll probably acclimate to it eventually, since it's fairly stable. I went to college in the New River Valley (in the Blue Ridge Mountains), and this was a problem for me for some time.
LIZARD