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Old 12-08-2007, 04:19 AM
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Join Date: Aug 2006
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15 yr Member
waves waves is offline
Legendary
waves's Avatar
 
Join Date: Aug 2006
Posts: 10,329
15 yr Member
Post SOME citrus - but not all

lime
SOUR orange or Seville oranges
possibly bergamot

have similar metabolic effects as does grapefruit, whereas

lemons
sweet orange varieties

appear to be safe.

tangerines and hybrids i don't recall reading about.

also, the effect on meds metabolism appears less related to originally the originally indicted flavonoid, but rather to the action of contained fumarocoumarins(hmm?), also present in smoke, smoked and charred foods (makes ya think about the "bitter" quality of these indicted citrus. These may affect UGT processes (a different enzyme system than the CYP group) as well - aside from the CYP interactions earlier mentioned. However those mechanisms, are, to me, not well understood. i can't recall yet if the article talked about the UGT processes wrt smoking. The effects i do know of regarding smoking pertain to the CYP interactions i.e. 1A2 increases olanzapine clearance but now i'm rambling waaaaaaayy off topic.

most of this stuff is the post-short-term-memory-impaired remnants of an article i read ... will find link for another time am sorry am not up to it.

such a good researcher i am these days. bad waves.
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