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Legendary
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Join Date: Aug 2006
Posts: 10,329
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Legendary
Join Date: Aug 2006
Posts: 10,329
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SOME citrus - but not all
lime
SOUR orange or Seville oranges
possibly bergamot
have similar metabolic effects as does grapefruit, whereas
lemons
sweet orange varieties
appear to be safe.
tangerines and hybrids i don't recall reading about.
also, the effect on meds metabolism appears less related to originally the originally indicted flavonoid, but rather to the action of contained fumarocoumarins(hmm?), also present in smoke, smoked and charred foods (makes ya think about the "bitter" quality of these indicted citrus. These may affect UGT processes (a different enzyme system than the CYP group) as well - aside from the CYP interactions earlier mentioned. However those mechanisms, are, to me, not well understood. i can't recall yet if the article talked about the UGT processes wrt smoking. The effects i do know of regarding smoking pertain to the CYP interactions i.e. 1A2 increases olanzapine clearance but now i'm rambling waaaaaaayy off topic.
most of this stuff is the post-short-term-memory-impaired remnants of an article i read ... will find link for another time am sorry am not up to it.
such a good researcher i am these days. bad waves.
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