Probably much more than 10 years....nobody knows what the gene product from the ramping down gene is. That is, if there even is a product. Some genes interact at the nucleic acid level---no protein intermediary.

The news of this article is that the unmodulated gene 1 [without the gene 2 present] seems to result in a disease similar to the rare and fatal form of MS.

That the histocompatibility locus is involved in autoimmune diseases has been known for decades. But MS is not a single locus trait, i.e., not simply inherited like brown eyes. There are still more genes to identify.

But interesting article---thanks for posting it.