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In Remembrance
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Join Date: Sep 2006
Location: about 45 minutes to anywhere!
Posts: 3,086
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In Remembrance
Join Date: Sep 2006
Location: about 45 minutes to anywhere!
Posts: 3,086
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The Ubiquitin Proteasome Pathway
The Ubiquitin Proteasome Pathway (UPP) is the principal mechanism for protein catabolism in the mammalian cytosol and nucleus. The highly regulated UPP affects a wide variety of cellular processes and substrates and defects in the system can result in the pathogenesis of several important human diseases. The central role of the UPP in biology has been recognized with the Nobel Prize for Chemistry which was awarded to Avram Hershko, Aaron Ciechanover and Irwin Rose in 2004.
The UPP is central to the regulation of almost all cellular processes including:
Antigen processing
Apoptosis
Biogenesis of organelles
Cell cycle and division
DNA transcription and repair
Differentiation and development
Immune response and inflammation
Neural and muscular degeneration
Morphogenesis of neural networks
Modulation of cell surface receptors, ion channels and the secretory pathway
Response to stress and extracellular modulators
Ribosome biogenesis
Viral infection
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with much love,
lou_lou
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by
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, on Flickr
pd documentary - part 2 and 3
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Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these.
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