there was orginally controversy about selegiline metabolizing to amphetamine-like substances, and the question whether these products were helpful or harmful in PD. Am unsure if a consensus has ever been achieved. One neurologist we consulted maintained these products may help with fatigue in PD, the other neurologist wanted to avoid selegiline because of the amphetamine like metabolites....As in many other treatment areas in PD, the reasons for using one specific MAO-B inhibitor over the other appears to be partially dependent upon the physician one consults.....