Thread: DQ question
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Old 12-21-2007, 07:49 AM
northernlights northernlights is offline
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Join Date: Feb 2007
Location: Norway Europe
Posts: 51
15 yr Member
northernlights northernlights is offline
Junior Member
 
Join Date: Feb 2007
Location: Norway Europe
Posts: 51
15 yr Member
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Here I found something on DQA1 *01 BQB1 *05 which is DQ1 or very close:
Db=pubmed&Cmd=ShowDetailView&TermToSearch=12651074 &ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.P ubmed_ResultsPanel.Pubmed_RVDocSum

"HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease
Genetic susceptibility to celiac disease is strongly associated with HLA-DQA1*05-DQB1*02 (DQ2) and HLA-DQA1*03-DQB1*0302 (DQ8). Study of the HLA associations in patients not carrying these heterodimers has been limited by the rarity of such patients. This European collaboration has provided a unique opportunity to study a large series of such patients. From 1008 European coeliacs, 61 were identified who neither carry the DQ2 nor DQ8 heterodimers. Fifty seven of these encoded half of the DQ2 heterodimer. The remaining 4 patients had a variety of clinical presentations. Three of them carried the DQA1*01-DQB*05 haplotype as did 20/61 of those carrying neither DQ2 nor DQ8. This may implicate a role of the DQA1*01-DQB*05 haplotype. None of these four patients carried the DQB1*06 allele that has previously been reported in this sub-group of patients. Of the 16 DQ2 heterodimer negative patients without DRB1*04 or DRB1*07 haplotypes, it was inferred that none encoded the previously implicated DRB4 gene as none had a DRB1*09 haplotype. These results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease, and the extreme rarity of celiac patients carrying neither the DQ2 or DQ8 heterodimers nor one half of the DQ2 heterodimer alone. Copyright American Society for Histocompatibility and Immunogenetics, 2003

PMID: 12651074
"
just type in the PMID nr and hit enter if the link here does not work

DQB1*06 is DQ1 if the alpha allele is 0101, maybe they mean DQ1 here too:
http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

altogether it looks like that there are celiacs out there who have half of the DQ2 or DQ8 genes but there are those who do not have half the DQ2 or DQ8 gene.
http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum
nora
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