I think an outside second opinion of her "whole " condition would be required by most drs, and most likely a good idea. Her local dr may be missing something or in the habit of Rrxing meds with out a full diagnosis workup.
What are her diagnoses and what medications is she taking?

We do have online medication interaction links that you can compare the various meds for safety that way. here - http://neurotalk.psychcentral.com/thread2864.html
Also our Medications forum- http://neurotalk.psychcentral.com/forum72.html

But otherwise it can be a individual reaction to the combo - some meds /combos work fine for some people and for some it doesn't.