many TBDs are commonly blood negative!!
Here you can see Ehrlichiosis was blood negative in 2 of 4 acute, fatal cases!
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
Evidence of E. chaffeensis via IHC, ISH, and PCR was documented in all 4 cases. Abundant immunostaining and in situ nucleic acid hybridization were observed in spleen and lymph node from all 4 patients.
Significantly, in 2 of these patients, serologic evidence of infection was absent.
UNQUOTE
Ehrlichiosis is a common lyme coinfection!!! And common by itself.
1: Arch Virol Suppl. 2005;(19):147-56.Links
Ehrlichia under our noses and no one notices.
Walker DH.
Department of Pathology, Center for Biodefense and Emerging Infectious Diseases
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum