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In Remembrance
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Join Date: Sep 2006
Location: about 45 minutes to anywhere!
Posts: 3,086
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In Remembrance
Join Date: Sep 2006
Location: about 45 minutes to anywhere!
Posts: 3,086
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for PD -AGT -190
AGT-190
A neuroprotection drug for stroke or Parkinson's disease
AGT-190 is a genetically engineered fusion protein that is comprised of a human neurotrophin that causes neuroprotection in the brain, and is indicated acutely for the treatment of stroke, and chronically for the treatment of Parkinson's disease (PD). The neurotrophin forming AGT-190 is a large molecule, which does not cross the blood-brain barrier (BBB), and cannot enter the brain following peripheral administration. The neurotrophin is fused to another protein that undergoes receptor-mediated transport across the human BBB; the second protein acts as a molecular Trojan horse to ferry the therapeutic neurotrophin across the BBB into brain from blood. The AGT-190 fusion protein is a bi-functional molecule: it both attaches to a receptor on the human BBB, to cause transport into the brain from blood, and it attaches to a specific neurotrophin receptor on brain cells to protect the cells from cellular damage. AGT-190 is the first neurotrophin treatment specifically engineered to cross the BBB for the long-term treatment of PD.
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with much love,
lou_lou
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by
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, on Flickr
pd documentary - part 2 and 3
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Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these.
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