Yes, Cindy. Benadryl or dyphenhydramine also used in Unisom was the first OTC antihistamine to be used in this country. We use it when people are having allergic reactions to anything. It's probably one of the quickest acting antihistamines available, although there are many others out there such as Zyrtec; however they are not used as much for immediate allergic reactions as Benadryl is.