I can look back at the last 10 years and see 5 of decline and 2 of Avonex and monthly steroids and feeling pretty crappy and not getting much better, then 3 and a half years on Rebif and getting better and better and better. I'd never have believed it possible 5 years ago that i could have recovered as much lost ground as I have especially with that horrendous foot injury thrown in the mix.

My recommendation: If you've only tried one thing and it hasn't worked, give one of the others a go. There's a good chance you'll hit on something that works for you.