Hi Howard,

I would like someone to please correct me if I am mistaken, but I think Neurologix gene therapy is for symptoms only - like a DBS. I don't think it is meant to regenerate, or grow new cells. Neurologix is not working on dopamine, they are working on inhibiting misfiring in another area of the brain. I don't know how long it lasts - I guess no one does? Let's hope for permanently.

from http://www.medicalnewstoday.com/articles/91995.php

The Neurologix procedure delivers a gene (glutamic acid decarboxylase, or GAD) to the subthalamic nucleus of the brain, where it makes an inhibitory neurotransmitter called GABA that helps to quiet the abnormal brain activity that is correlated with motor deficits characterizing Parkinson's disease. Results of a Phase 1 clinical study showed that the Neurologix gene transfer procedure was both well tolerated and resulted in improved motor function and brain metabolism for patients with advanced Parkinson's disease over the course of the one-year study. Neurologix is currently preparing to initiate a Phase 2 study of its Parkinson's disease treatment by early 2008, subject to final FDA consent to the study protocol.

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This is different from Ceregene, whose trial is with a growth factor that could repair and regenerate growth. [Neurturin] Fox is heavily invested in this and their head science advisor was involved in discovering it. it's a substitute for GDNF since it is not available.

I have no idea why MJFF isn't involved with Neurologix, just related thoughts.

paula