in our Health News Headlines today on NeuroTalk:
http://news.yahoo.com/s/hsn/20080116...erstatedreport
Some day soon I hope we will see a similar review for the studies on cholesterol meds.
Antidepressant Effectiveness Probably Overstated: Report
Quote:
WEDNESDAY, Jan. 16 (HealthDay News) -- A systematic review of studies on antidepressants concludes that the positive effects of these drugs are probably overstated in the medical literature.
But it's not clear if the bias comes from a reluctance to submit negative manuscripts or decisions by journals not to publish them, or a combination of both, according to Oregon Health and Science University researchers, whose report is published in the Jan. 17 issue of the New England Journal of Medicine.
The researchers compared drug efficacy inferred from published studies with drug efficacy reported to a mandatory U.S. government registry of clinical trials, in which all results, including raw data, must be included.
Only 51 percent of studies in the U.S. Food and Drug Administration registry were considered by the agency to have positive results.
In the published medical literature, however, 94 percent of studies appeared positive.
The increase in the effectiveness of the drug ranged from 11 percent to 69 percent for individual drugs, and was 32 percent overall. The antidepressant Wellbutrin appeared to show a high level of bias.
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There is more, the article is long, and it is worth reading the whole thing!
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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