Hi Sarah -
Wow! that was a lot of info, thanks for putting it all together for me! Unfortunately, I'm fairly sure that I can't blame this on lyme. My mom was dx'd 36 years ago, long before the advent of lyme disease. She had lesions and a positive LP. She definitely has MS.

I actually grew up in CT (birthplace of Lyme disease!). Had it at age 18. Was treated with abx within 3 weeks of the bite and had a full recovery. At 31 I had a positive MRI and a positive LP with plenty of O-bands to indicate demylination.

My brother may have had lyme disease as well. I'm not sure. He also showed lesions and had a positive LP.

The fact that we have 3 positive LPs as well as lesions leads me to believe that this is not a lyme disease issue.

Luckily for now, my brother and I are both infraclinical/subclinical since we haven't had exacerbations yet. Lucky us that our lesions are all silent, but it doesn't say much for the amount of brain we use