It took me 5 months to wean off Zoloft after 4 years on it. The last two weeks of 25mg daily, I felt horrible. Achy, hot/cold, cramps, headache, couldn't concentrate. Same for the first week off it. Then my neuro gave me a gram of Solumedrol IV and the symptoms of withdrawl disappeared in less than two hours after experiencing them for three weeks non-stop.