Hi, I'm a regular on the Parkinson's disease forum. Chemar, Curious, jo55 and kimmydawn will recognize me as that nutty white rat Professor who thinks that low-dose dextromethorphan is providing him with neuroprotection. For your information, it has been demonstrated in laboratory animal brains that several drugs in the morphinan class, which includes naloxone, naltrexone and dextromethorphan prevent the inflammatory response of brain microglial cells to LPS (bacterial cell wall lipopolysaccharide). These compounds are effective at unbelievably low concentrations. This may be the basis of the apparent effectiveness of the low-dose naltrexone (LDN) treatment made famous by Dr. Bihari in New York. According to reports, a very large number of MS patients are achieving complete cessation of MS crises with this medication.

I have chosen to use dextromethorphan in cough preparations such as Pedia Care Long Acting instead of naltrexone since it is available over the counter, whereas naltrexone requires a Rx. I have been taking 4-6mg each night at bedtime since 2002, and have experienced very little, if any, progression of my PD.

I would like to hear from members of this forum whether and how many of you have heard about LDN, or are currently taking it. Please feel free to pm me if you prefer not to respond on the forum.

Thanks, Robert