Carolyn...........I have been on Rebif for 4 going on 5 years. The headaches are the number 1 side effects. The home nurse from Serono/Pfizer that comes to see me, told me to take aleve about 30 min. before my shot and about 4 hours later try excedrin migraine. Keep well hydrated and take the shot early enough in the evening so I am sleeping through the worst of it. Rebif peaks at 8 hours, keep that in mind.
Even after all this time, I understand the crummies......and there are times I really have to convince myself that, "this is better than the alternative!"
Feel free to PM me if you have any questions........Barb