Joelle, I was told to take .25 mg about 30 to 45 minutes prior to infusion. I have not noticed being more tired. I have experiencd a slight headache and mild nausea for about one day.

Chris, Unfortunately, I had a reaction during my second infusion so I am going to try the premedication. Neuro did not think it was too bad of a reaction. Of course he was not the one who had trougle breathing