It seems like you would only need to skip a couple of shots to know, since the dosing is frequent. Some people just can't do interferons.

Did you try varying your analgesic when you pre-medicate? The one that was no fail for me when I used Beta was, seriously, beer. I didn't have one flu symptom from day one.

If you can get the go ahead for Tysabri, maybe you should jump at that anyway.