--about new formulations, especially combos.

I tend to agree with Brian as regards the calcium/magnesium; since they tend to act agonistically in the body, though (both, chemically, being alkali metals), you might want to take them seperately.

One thing I can vouch for is that the new R-lipoic acid forumlations have been, at least for me, just as powerful as the alpha-lipoic acid formulations, on about a 6:1 to 10:1 ratio; I seem to get roughly the same effect from 100mg of R-lipoic as 600-900 of alpha, and am taking only one of these a day--I used to take the alpha broken into subdoses, due to the acidity, but that doesn't seem to be as much of a problem with the 100mg of R (though I do take it with breakfast, just in case).