I've read many claims about sublingual/buccal absorption. Also many papers.
What I see is that sublingual/buccal route is very iffy. It is not suited to many types of compounds, and requires TIME ...
This paper, gives some parameters for it..and you can see how complex it is.
http://www.ualberta.ca/~csps/JPPS1(1...ccalreview.htm
We do not see RX drug dosage forms commonly for this route. Fentanyl immediate release, nitro, some nicotine lozenges are basically it. This is because to get reliable absorption is not easy.
I don't see ANY OTC manufacturer spending any $$ to create bioavailability studies for any vitamin used sublingually. The FDA does not demand it, and therefore it is not done. Studies have shown that swallowed B12 taken daily, will improve blood levels in time as well as IM injections.
Here are other examples comparing oral vs sublingual:
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
and this:
Quote:
Br J Clin Pharmacol. 2003 Dec;56(6):635-8.Click here to read Click here to read Links
Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route.
Sharabi A, Cohen E, Sulkes J, Garty M.
Recanati Center for Medicine and Research and Clinical Pharmacology Unit, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AIMS: To compare the efficacy of sublingual and oral administration of 500 micro g of cobalamin in subjects with cobalamin deficiency. MATERIALS AND RESULTS: Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to receive one tablet daily of 500 micro g cobalamin sublingually or orally, or two tablets daily of a vitamin B complex. Serum cobalamin concentrations before treatment were 94 +/- 30 pmol l-1, 108 +/- 17 pmol l-1 and 98 +/- 14 pmol l-1 in the sublingual B12, oral B12 and oral B-complex groups, respectively. After 4 weeks, concentrations rose to 288 +/- 74 pmol l-1, 286 +/- 87 pmol l-1 and 293 +/- 78 pmol l-1, respectively. The increase in each group across time was statistically significant (P = 0.0001, differences [95% confidence intervals] 194.2 (114.5, 273.9), 178.3 (104.2, 252.4), and 195.1 (135.0, 255.2) pmol l-1, respectively). There was no significant difference in concentrations between the treatment groups. CONCLUSION: A dose of 500 micro g of cobalamin given either sublingually or orally is effective in correcting cobalamin deficiency.
PMID: 14616423 [PubMed - indexed for MEDLINE]
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What IS important is that taking an oral dose should be done on an empty stomach... because microgram doses of anything are not absorbed well with food present. (also goes for thyroid replacement and digoxin treatment).
There have been rare individuals who react to the cyanide portion of the cyanocobalamin. But that is not common. This was demonstrated in patients with Leber's optic neuritis. This is thought to be due to a genetic failure in handling cyanide.
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Weezie looking at petunias 8.25.2017
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