My personal experience was that the Sinemet CR did not have enough "oomph!" at the beginning of the dose to reach a level to ever kick in. Maybe is they came up with a higher dosage of the CR, it would be more helpful for some. I know there are others on the site who find it very helpful.

Maybe this would be a good question for "Ask the Doctor" at the National Parkinson web site.

Peace to you,
Vicky