Hi Renee, I am one of those 'interferon intolerant' mser's. I was Avonex for 9 really bad weeks. I never stopped having the flu-like symptoms. Fever, worse than my usual exhaustion, my right eye nearly swelled shut. My dh finally looked at me one day and said enough is enough. It got to the point where I felt like I was poisoning myself when it was injection time. I can't use Copaxone because of severe site reactions. I'm happy to say that I will be starting Ty within the next week or two. My last Avonex shot was on Thanksgiving day, so I'm well passed the washout time. I did fall into a relapse even before I went off of the Avonex and I'm still dealing with that. I'm just looking at this as a new and hopefully better way to deal with this crazy disease. Good luck and I hope you feel better off of the interferon, if that's what you really want to do.