Unfortunately, twist and sprain injuries are very common in people with neuropathy, as the garbled nerve signals mess with our proprioceptive (bodily feedback) abilities, and often we move joints further than they were intended to be moved without knowing exactly how far we've gone--until it's too late. Not to mention the degree to which neuropathy can interfere with our pain signalling systems.

Mr.s D is quite right--any major twist or turn in the ankle area is worth an x-ray to check out the bone/tendon attachments, an dmay require immobilization. (My 9-year old son got a grade 4 low left ankle sprain last year--about as bad as you can get without a break--and he was sat down for nearly six weeks. We still have him wear a sleeve when he plays basketball.) The ankle area does not heal as rapidly as many others--for the same reasons that many neuropathies start in those distal areas; the region does not have as good a blood supply as others, and blood must ravel farther, and it's easy to disturb transportation of oxygen and nutrients to the area and transport of fluid and waste products out (especially with inflammation).