I went thru some serious issues with it at the start of my illness. I lost 25 - 30 pounds in less than 2 months, nothing seemed to be reliable help. Constant nausea, just didn`t feel like eating. Later it changed to constipation.

I told my PCP, had a colonoscopey done and no problems there to speak of. I do have spinal lesions, so maybe?

I take generic Metamucil regularly now and not many problems.