I have been on sinemet mfore than 10 years and have tried many combos.

I now take CR 25/100 ...up to 10 a day. Some days I get by on 7 or 8
and some days 10 or 12...I just do what I need to do to keep going.

The regular sinemet, my body/brain just burns up like candy and only lasts me 2-3 hours maxz ...I get wired and have way toooo much adrenaline in my system. The Neuro's have no idea why this happens. The CR provides a sort of rationing and I cruise along nicely most days on a 2 hour schedule. The Mvmt disorder clinic doesn't like the way I do things, but has to admit I'm doing better than they would have expected, no real problems with dyskinesia, UNLESS I've eaten a lot of high sugar/high fat foods.

This is a disease that definitley does not follow any set of rules. What works for one does not work for another. Try all the options and document all the responses, then pick the one that works the best for you...until it doesn't anymore, then start again. Welcome to Wonderland!