http://www.rxlist.com/cgi/generic2/p...igmine_ids.htm
Really rapid GI transit times, with the flu etc would be a problem.
But transit of 8 hrs may not significantly alter the sustained release as much.
Quote:
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Timespan Tablets each containing 180 mg pyridostigmine bromide. This form provides uniformly slow release, hence prolonged duration of drug action; it facilitates control of myasthenic symptoms with fewer individual doses daily. The immediate effect of a 180-mg Timespan Tablet is about equal to that of a 60-mg Conventional Tablet; however, its duration of effectiveness, although varying in individual patients, averages 2 1 / 2 times that of a 60-mg dose....Timespan Tablets One to three 180-mg tablets, once or twice daily, will usually be sufficient to control symptoms; however, the needs of certain individuals may vary markedly from this average. The interval between doses should be at least 6 hours. For optimum control, it may be necessary to use the more rapidly acting regular tablets or syrup in conjunction with Timespan therapy.
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also this is helpful:
http://www.rxmed.com/b.main/b2.pharm.../MESTINON.html
In general people vary in response to this drug:
http://jnnp.bmjjournals.com/cgi/cont...ract/46/10/929
There may be other reasons besides GI transit times.
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Weezie looking at petunias 8.25.2017
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