I started Betaseron in October 2007. I have a Beta Nurse who is very helpful and provided numerous tips for injecting.
I have only had a couple of the red site reactions, they do tend to last a while but not such a big deal. A few bruises, mostly in the arms but they didn't last long.
No flu-like symptoms but did premedicate for a few weeks until I was sure I didn't have any of those reactions. I did have some burning while injecting the first three months but no longer have that.
I chose Beta after the name was presented to me by my neuro's nurse. She didn't promote it necessarily but told me to research it and all the others. I decided Beta was the best choice for me after adding up all the pros and cons. You can see a chart at the National MS Society Site. My neuro will do blood work every three months to check on liver/thyroid function.
I also use the autoinjector because I do not care for needles and it's not so bad when you can't see it in the injector. Or so I tell myself.
Best of luck in your journey!