I started Beta Aug O7 after 6 years of Avonex. I switched because my neuro found a lesion on the MRI. While every other day shots can be a drag, compared with the weekly Avonex, they're not bad. I don't need to premedicate anymore, but the red splotches can be wicked. Some are just cosmetic, but some are pretty sore for a couple of weeks. During the first couple of months, I didn't know if I'd be able to continue, but it's getting better. As long as it's doing the job, I'll put up with the inconvenience and ugly legs.