My daughter was on Amitriptyline for several weeks and then another doc recommended Effexor XR, which she now uses. Fewer side effects and more precise dosing. These are classified as antidepressants, but the way it was explained to us, they're used in TBI to help re-establish nerve pathways in the brain. Fortunately, her attitude has always been positive. (More than I can say for myself, at times!) Also found help with acupuncture, and now osteopathic manipulation and homeopathy. Hang in there!