I have been on either neurontin or Lyrica for the past 5 years or so and can't say that i have never had a problem. They posted a similar warning for the interferons too and again, it has not been a problem and i do have a history of severe depression in the past so i was worried when i started the betaseron. I would hate to see people stop taking these meds when they are getting pain relief from them- obvioulsy if some one is feeling depressed or having suicidal thoughts they need to talk to their MO - then its for the MO to work out wether the meds are the problem or not- but thanks for the info