GJ, I am so sorry you're going through all of this. I really don't have any advise or suggestions. I was diagnosed without an LP and have never had one done.

My MRI was suggestive of a demyelinating disease and I had symptoms that corresponded with those of MS. All other possibilities were ruled out via blood tests, exams, referrals, etc.

I am very cautious about where I get my information from on the internet though. Some sites are not as good as others. Please, keep that in mind when researching.

As for the O bands as well as lesions, I know a simple virus can cause both but not be MS at all. Additionally, migraines can cause lesions.

There is nothing wrong with asking for a 2nd opinion. Please let us know how it goes. Take a deep breath and try to relax. (easier said than done, I know, but try).