I think it is far to early to start thinking cause and effect just yet, as has been pointed out, both patients had family history of melanoma and were in there 40's, about the age when we have to start being more observant about changes in moles etc. plus there have been very active campaigns recently warning of the dangers of melanoma so i think that has had the desired effect of making people have lesions checked more- so lots of potential reasson why these 2 case were unfortunate enought to end up with melanoma to deal with as well as MS. When they list adverse effects of drugs they basically just list any anbnormal subjective and objective finding/complaint that the patient presents with, then gradually over time they try to work out if there is a reason for a direct cause and effect link bewtween the 2, so it will be quite some time before we know for sure and you will probably read alot more potentially unsettling reports too. If you looked through the drug manuals for just about any prescription medication at the adverse effects, you would be amazed!