i have had the opposite side effect from wellbutrin. It has helped my pain. When i forget to take it for a day, i am reminded by an increase in pain. It is the only anti depressant that has helped my pain. Effexor, paxil, buspar, remeron...nada.......I am very atypical for many medications though...either they dont work on me or they effect me in negative ways such as not being able to stay awake, feeling sick etc.