Hi there...I have full-body, systemic RSD and was put on Topomax after being on Neurontin and Lyrica...Both of those made me very sick and nauseated and I also gained weight on Lyrica...I have been on Topomax 100mg for 1.5 years with time off for a pregnancy. I started at 25mg and increased weekly to 100mg. Topomax has been wonderful for me. I have noticed a significant decrease in nerve pain and burning than what I would normally be dealing with.
I will be honest with you.There are a lot of side effects that people complain about like: blurred vission, loss of appetite, weight loss, confusion, irritability, and nervousness. A couple of these affected me at first, but as my body adjusted, they went away and I don't have any anymore.
I hope this helps...Please feel free to ask me any questions.

,
Heather