Rick, where did you get the raw powder? Is it Zandopa (HP200)? That's what they used in a clinical trial.
Thanks.


Research Article
Bioavailability of L-DOPA from HP-200 - a Formulation of Seed Powder of Mucuna pruriens (Bak): a Pharmacokinetic and Pharmacodynamic Study

Abstract
HP-200, a formulation made from the seed powder of Mucuna pruriens, contains among other constituents, about 4% L-DOPA. After five normal human volunteers were each given a single oral dose of 30 g of HP-200, plasma samples were obtained at 0, 20, 40, 60, 90, 120, 180, 240 and 360 min for assay of L-DOPA by HPLC technique using electrochemical detection. The supine systolic and diastolic blood pressures were recorded at each sampling time.

The results indicate that on oral administration, L-DOPA was absorbed from HP-200 with plasma peak levels (Cmax=1.56±0.163 g/mL) achieved at Tmax=83±16.09 min. The plasma half life was 102±2 min and the auc was determined as 6.508±0.421 g/h/mL.

The pharmacokinetic profile of HP-200 exhibited characteristics similar to formulations of synthetic L-DOPA, except for the lack of a sharp peak. HP-200, a new herbal formulation, appears to be suitable for the treatment of Parkinson's disease.

http://www3.interscience.wiley.com/c...22064/ABSTRACT