"Doses of HP-200 were started at 7.5 grams (which provided a standardized amount of levodopa), three times a day. Doses were then increased at weeks two and four to obtain the best response. The average daily dose by the end of the 12-week study was 45 grams of HP-200. Side effects were minimal. Those who had not taken levodopa medications prior to the study, tolerated HP-200 best."

I don't know when improvements were first seen and at what dose.

http://content.herbalgram.org/wholef...ew.asp?i=42085

COMPREHENSIVE REVIEW OF MUCUNA HERE (2007):

http://www.phcogrev.com/issue1/19.pdf

Article says mucuna contains NADH and COQ10 and it increased mitochondrial Complex 1 activity.