Quote:
Rev Port Cardiol. 2007 Jun;26(6):609-19.Links
Endothelial dysfunction in type 2 diabetes: effect of antioxidants.
[Article in English, Portuguese]
Sena CM, Nunes E, Louro T, Proença T, Seiça RM.
Instituto de Fisiologia, Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal.
Individuals with insulin resistance and diabetes mellitus have increased cardiovascular morbidity and mortality, caused in part by vascular complications. Endothelial dysfunction has been implicated in the pathogenesis of vascular diabetic disease. This abnormal function of the vasculature precedes cardiovascular disease and is associated with impaired endothelium-dependent vasorelaxation. The main etiology of the increased mortality and morbidity of type 2 diabetic patients is atherosclerosis. Increased production of free radicals is associated with the pathophysiology of diabetes, resulting in oxidative damage to lipids and proteins. Reduction of oxidative stress in diabetic patients may delay the onset of atherogenesis and the appearance of micro- and macrovascular complications. Alpha-lipoic acid (LA) is a multifunctional antioxidant that has been shown to have beneficial effects on polyneuropathy and on markers of oxidative stress in various tissues. This study was conducted to investigate the effects of LA on endothelial function in diabetic and hyperlipidemic animal models. Carbohydrate and lipid metabolism, endothelial function, plasma malondialdehyde (MDA) and urinary 8-hydroxydeoxyguanosine (8-OHdG) were assessed in non-diabetic controls (Wistar rats), untreated diabetic Goto-Kakizaki (GK) rats and, atherogenic diet (AD)-fed GK rats (fed with atherogenic diet only, treated with alpha-lipoic acid and treated with vehicle, for 3 months). AD resulted in a 3-fold increase in both total and non-HDL serum cholesterol levels and in a 2-fold increase triglyceride levels while endothelial function was significantly reduce MDA and 8-OHdG levels were higher in the GK and GK hyperlipidemic groups and were completely reversed by the antioxidant. Hyperlipidemic GK diabetic rats showed significantly reduced endothelial function that was partially improved with LA. Furthermore, lipoic acid significantly reduced serum cholesterol levels, without lowering HDL cholesterol. Alpha-lipoic acid supplementation represents an achievable adjunct therapy to improve endothelial function and reduce oxidative stress, factors that are implicated in the pathogenesis of atherosclerosis in diabetes.
PMID: 17849945 [PubMed - indexed for MEDLINE]
|
It is not clear to me in the paper you posted, if the T4 and T3 were given to euthroid people...or hypo people.
You might want to read this list :
http://www.raysahelian.com/lipoic.html
Quote:
Alpha lipoic acid side effects
There are no indications that low doses of lipoic acid, such as 5 to 20 mg, have side effects. Higher doses could cause nausea or stomach upset, along with over-stimulation, fatigue, and insomnia. High doses could also potentially lower blood sugar. This is often beneficial to patients who have diabetes, but it requires close monitoring of blood sugar levels. We have had one report of 300 mg of alpha lipoic acid taken 3 times a day for three weeks led to atrial fibrillation. Another person emailed that a 50 mg dose of R lipoic acid made him feel his heart racing, he took it at the same time as his thyroid medication Levothyroid. Those with thyroid problems may consider taking half a capsule of a 50 mg R alpha lipoic acid dose.
|
I have found that 100mg of R-lipoic is doing wonderful things for me.
I don't feel any loss of thyroid function at all. And I can't take it after noon, or I can expect some difficulty falling asleep.
In fact I just bought refills.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.