I take my lase Prednisone at 8 pm, and yes I am wide awake at about 4am every morning, but because of other medications this is the only time I can take it. I'm not gaining weight although I am swelling up in the face. Because of the disease I lost 35 pounds pretty suddenly, so the prednisone puffiness is actually making me look less haggard, the only side effect so far that could be a plus. Yes I itch, twitch and legs cramp when I wake at 4. I was prescribed Benadryl to stop the itchyness caused by the jaundice so I know that is safe for me to take.

Thanks