I have small fiber neuropathy, myopathy, likely due to a hereditary neuropathy and/or anterior horn cell disease, and yes, I do have fasciculations, frequently.

I was diagnosed through intraepidermal nerve fiber density testing (skin biopsy), abnormal tilt table testing, global anhidrosis via thermoregulatory sweat testing, abnormal cardiac stress tests with significant hypotension with exertion, abnormal gastric motility testing, and muscle biopsy (neurogenic-angulated fibers) in the bicep.

I have sensory and autonomic neuropathy and given the recent muscle biopsy finding, likey a motor component as well.

Fasciculations also occur with some anterior horn cell diseases which need to be ruled out.

Have they ruled out Charcot Marie Tooth Disease (Hereditary Neuropathy)? Recently there has been a surge in the genotyping, and there are quite a few known gene loci. Of course, there are many that are still unknown.

Some adult onset myopathies are also accompanied by neuropathies as well.

It is important that the PN be defined as demyelinating or axonal, and that the cause be thoroughly explored as some PN is treatable.

PN is a broad term that indicates nervous system disease that does not involve the brain or spine (central nervous system).