Having been on Rebif and Avonex, fixing to start Copax! I can tell you that different areas hurt differently with different shots! So give Rebif a chance in all areas before deciding.

Rebif was given to me manually by my husband, as I physically was unable to do the shots. I always ibuprofened up, but never iced Rebif.... Rebif was prone to burning while administering....don't know why....

Good Luck