i am still in the early shock stage due to very recent diagnosis but i drilled my opthamololgist about the brain damage/location correlation...my lesion does not seem to be impacting my symptoms (double vision) apparently ms can be manifested through this optic nerve connection...still have to keep the darned prism thing on my glasses and hope that my vision improves...apparently my eye isn't moving as much to the right but my vision still needs the prism connection... also saw my lady dr today for the annual exam and she kept asking me if i had notices any muscle weakness???? not any more than usual....given chasing two kids...not really exercising that much (except the 37 stairs up to our house) but not really feeling it...